Intolerance Test

Items included within our Intolerance test:

What's inside the testing kit?

1 x Alcohol wipe
1 x Band-aid
1 x Absorbent pad
1 x Five Spot Blood Card
2 x Lancets CE 0344 (pin-prick system)
1 x Return envelope
1 x Activation card with an adhesive label

How to take your sample

1

Receive your testing kit in the mail

2

Clean your finger and use the finger prick to take your sample

3

Fill the blood spot card with your sample

4

Mail your sample to our labs for testing

The Science

This test uses the IgG4 in your blood sample for intolerance testing, but what does that mean?

IgG and IgE antibodies play an important role in our immune system. The immune system helps our body to fight infections and inflammation caused by external invaders known as antigens like viruses, bacteria, parasitic worms and proteins. We have four classes of IgG antibodies: IgG1, IgG2, IgG3 and IgG4(1). For the Intolerance Test, we are using IgG4 to help us in the identification of those non-immunological responses that can be the cause of common symptoms like bloating, headaches, stomach pains and diarrhea.

Why IgG4?

The IgG4 antibodies can influence the inflammatory response but not activate it. We are using IgG4 in our intolerance tests because we are investigating delayed symptoms that could be associated with food and non-food intolerances (1,2). These do not cause an immediate immunological response, however, could still be causing you problems. For food intolerance, the presence of specific IgE and IgG antibodies can be observed. Some subclasses of IgG (mainly IgG4) inhibit the degranulation of basophils and mast cells and the activation of the complement cascade (2).

At Test Your Intolerance, we use IgG4 exclusively for qualitative intolerance testing. Our tests are not used for the diagnosis of acute or chronic food intolerances; however, we are helping you to draw a map of the reactions that could be the cause of your symptoms. 60% of the world’s population suffers from food intolerance to at least one food antigen. This test is not a quick fix but can help you in your journey to find a better version of yourself. To find out more about the science of IgG4 testing, click here.

References

1. Aalberse RC, Stapel SO, Schuurman J, Rispens T, Immunoglobulin G4: an odd antibody. Clin Exp Allergy. 2009; 39(4): 469-77.
2. Velikova T et al. Methods for detection of food intolerance. RAdvFoodSci: 2018: 1(3): 106-119

• Removal of raised IgG4 items may improve lifestyle based on testimonial evidence.
• CE approved sample collection kit.
• Results do not constitute a medical diagnosis on their own, but may be used by your doctor or nutritional therapist to help form a diagnosis or rule out a condition.
• Quantitative data using an ELISA testing methodology. All values measured in Kilounits per antigen per litre (KUA/L), our scale uses a universal cut-off point of 0.35 in classifying a reaction.
• >97% reproducible results. IgG4 values may change over time with diet.

Important

Blood (ELISA) tests define an intolerance/sensitivity as a specific IgG4 antibody reaction and an allergy as a specific IgE antibody reaction (IgE-Mediated).

All information in the reports produced is intended to support nutritional advice to optimise your diet. The results cannot be used to diagnose, treat or cure medical/health conditions.

The use of antihistamines prior to or during the blood sample collection process may affect your results, please contact our team for further advice.

Always seek the advice of your doctor or other qualified health providers if you have a medical condition and/or medical symptoms. Never disregard professional medical advice or delay in seeking it.

• Same day dispatch on orders placed by midday
• Easy return envelope enclosed with your kit
• 14-day cancellation period if you change your mind
• Fast track option available at the checkout, get your blood results within 48 hours of your sample arriving at our laboratory